Downregulated proteins (42/151) show enrichment of “presynapse,” “synaptic membrane,” and “presynaptic cytosol” (Fig. 2H and S3B, lower panel; supplementary dataset 5), which include the AD-associated proteins APP, CLU, MAP2, and serine/threonine-protein kinases A, B, and G. This evidence concerns the gene APP and Alzheimer disease.