For example, the end-diastolic volume (EDV) differentiates between concentric and eccentric remodeling patterns9 and the left-ventricular ejection fraction (LVEF) or LV systolic function is a powerful predictor of cardiac mortality on its own.10–13 Furthermore, differentiation of heart failure with reduced EF (HFrEF) from heart failure with preserved EF (HFpEF) is important since there exist clinically proven treatments to improve morbidity and mortality in HFrEF but for HFpEF there is only the recently approved SGLT2-inhibitors.14,15. The gene discussed is SLC5A2; the disease is heart failure.