Initially, the expression of 29 different m7G-associated genes was analyzed, revealing AGO2, DCPS, EIF3D, EIF4A1, EIF4E1B, GEMIN5, LARP1, METTL1, NCBP1, NCBP2, NCBP2L, NSUN2, NUDT3, NUDT4, and WDR4 to be upregulated in CRC patient tumor tissues, whereas CYFIP1, EIF4E3, EIF4G3, IFIT5, NCBP3, NUDT10, NUDT11, and NUDT16 were downregulated in these tissues (Fig. 1A). This evidence concerns the gene METTL1 and neoplasm.