Moreover, we performed logistic regression multivariable models where we combined the biomarker value of the different measured cytokines, and we observed that the combination of the categorical values of filaggrin, MCP-1 and IL-1β (applying Youden index cutoff values) is a good biomarker for viral infection predisposition, having an AUC of 0.72, with 68% of sensitivity and 85% of specificity, that can help in differentiating neonates with RVI risk at NICU (Table 2). The gene discussed is FLG; the disease is viral infectious disease.