To test a role for IL18r signaling from WAT adipocytes in controlling obesity and glucose intolerance, we bred the AdipoqCre mice with the Il18rfl/fl mice to generate adiponectin-positive adipocyte-selective IL18r-deficient Il18rfl/flAdipoqCre mice. The gene discussed is IL18R1; the disease is obesity due to melanocortin 4 receptor deficiency.