Gazzano et al. uncovered that combining H2S and doxorubicin yields a significantly greater efficacy than monotherapy with doxorubicin alone against osteosarcoma with a high P-gp expression because H2S reduces the efflux of doxorubicin from osteosarcoma cells by inhibiting P-gp, thereby enhancing its therapeutic efficacy [20]. The gene discussed is PGP; the disease is osteosarcoma.