KDM5B deficiency enhanced the expression levels of endothelial marker genes, including vascular endothelial growth factor A (Vegfa), Cd31, vascular endothelial growth factor receptor 2 (Vegfr2), nitric oxide synthase 3 (Nos3) and von Willebrand factor (Vwf), in myocardial tissues after MI (Fig. 6a). Here, NOS3 is linked to myocardial infarction.