ACAT1 and neoplasm: Considering that drastic downregulation of ACAT-1 correlated with the enhanced anti-tumor activity of CDDP in combination with ATV in MDA-MB-231, one can speculate that restoration of CDDP activity observed in the presence of ATV in CDDP-resistant TNBC also results from ACAT-1 downregulation and reduced CE availability.