In addition, the TLS-hi subtype had a more powerful immunostimulatory profile, high expression of chemokines, a higher enrichment in human leukocyte antigens (MHC) and TCRs, and a higher score of tumor-infiltrating immune cells (TIICs) (CD8 T, dendritic cell, macrophage, NK, Th1) effectors (p < 0.0001), demonstrating a better function of these immune cells (Fig. 2F, G). Here, CD8A is linked to neoplasm.