Recently, TLSs in HNSCC have been investigated through IHC analysis and verified to be associated with decreased p53 and Ki-67 scores, enriched filtration of CD8 + cytotoxic T cells and CD57 + NK cells, and improved survival rates[11, 12] However, no in-depth study has been conducted with regard to molecular mechanism and functional diversity between different TLS subtypes. Here, CD8A is linked to head and neck squamous cell carcinoma.