HK2 and obesity due to melanocortin 4 receptor deficiency: Nevertheless, given the proposition that high galectin-3 has a protective effect on obesity and diabetogenesis under overnutrition15,18,19, our results support a notion that the LPS/galectin-3-mTOR1 signaling pathway promotes glucose uptake and glycolysis through regulating the expression of the glycolytic genes including GLUT1, HK2, and PKM2, thereby functionally contributing to glucose homeostasis and diabetogenesis.