Finally, to further extend our observations to clinicopathologically relevant settings, Kaplan-Meier survival analysis of the Human Pathology Atlas database (https://www.proteinatlas.org/ENSG00000131981-LGALS3/pathology/liver+cancer) indicated that HCC patients with high expression of galectin-3 experienced a significant unfavorable survival (Fig. 7c). Here, LGALS3 is linked to hepatocellular carcinoma.