Nevertheless, given the proposition that high galectin-3 has a protective effect on obesity and diabetogenesis under overnutrition15,18,19, our results support a notion that the LPS/galectin-3-mTOR1 signaling pathway promotes glucose uptake and glycolysis through regulating the expression of the glycolytic genes including GLUT1, HK2, and PKM2, thereby functionally contributing to glucose homeostasis and diabetogenesis. The gene discussed is LGALS3; the disease is obesity due to melanocortin 4 receptor deficiency.