LGALS3 and hepatocellular carcinoma: However, analysis of the public datasets in Oncomine (https://www.oncomine.org/) showed that galectin-3 is highly expressed in a number of malignancies; galectin-3 mRNA level is significantly upregulated in thyroid gland papillary carcinoma, prostatic intraepithelial neoplasia, and especially in HCC (Fig. 6b).