Our sequencing data, as well as publicly available two RNA sequencing (RNA-Seq) and one single-cell RNA-Seq data, revealed that both IL-17 receptor A (IL17RA) and thrombospondin 1 (THBS1) mRNA levels were elevated, but the hsa-miR-29a-3p level was down-regulated, in PBMCs from the severe group, when compared to those from HCs and mild group of COVID-19. The gene discussed is THBS1; the disease is COVID-19.