Therefore, mean methylation rates and mRNA expression of genes involved in dopaminergic neurotransmission as well as in synapse formation, function, and preservation, namely Drd2 and the “synapse-co-factors” DISC1, Syp, and Dtnbp1, were investigated in the cingulate and prefrontal cortex being in scope of current schizophrenia research15 and finally correlated with each other. The gene discussed is DRD2; the disease is schizophrenia.