To investigate the potential prognostic significance of lipid metabolism-related proteins following surgical castration and Rosuvastatin treatment, we measured the levels of HMGCR, SLDLRP1, AKR1C4 and ABCA-1 at baseline, after 3 and 6 months of castration in statin and non-statin users PC patients. The gene discussed is AKR1C4; the disease is pachyonychia congenita.