HIF1A and cancer: In summary, based on WES and WGS data, we conclude that OD and MS are cancer susceptibility syndromes characterized by cartilage and vascular abnormalities and mainly caused by pathogenic variants in HIF1A, VHL, IDH1, and, possibly, other genes related with the HIF-1 pathway such as IDH2, KDM4C, or CDKN2A.