VHL and von Hippel-Lindau disease: The VHL-p.Arg210Trp variant is classified as pathogenic at the UMD-VHL mutations database (http://www.umd.be/VHL/) and, while it has not been described as causative of VHL syndrome, it has been described as causative of oligoastrocytoma at the VHLdb (http://vhldb.bio.unipd.it/mutations).