To understand the interaction between AD model cells and CRC cells, we co-cultured Aβ1–42 treated HT22 cells with CT26 cells in the current study, and we found that Aβ1–42 treated HT22 cells induced downregulation of FERMT2 and inhibited the migration, invasion and EMT in co-cultured CT26 cells. Here, FERMT2 is linked to Alzheimer disease.