DDX53 and Alzheimer disease: To validate whether FERMT2 in AD model cells plays a role in inhibiting the migration and invasion of CT26, HT22 cells were transfected with the FERMT2 overexpression plasmid before the Aβ1–42 (40 μM) exposure for 24 h and the protein levels of FERMT2 were detected by western blot assay (Fig 9A).