This anti-HIV effect has been previously demonstrated by the absence of HIV infection in the whole blood compared to the presence of infection in the lymphoid nodules under the same in vitro conditions [49], as well as in the easier replication of the virus in the whole blood of individuals with inherited Serpin A1 deficiency, compared to the lower infection rate in the whole blood of healthy controls [50]. This evidence concerns the gene SERPINA1 and HIV infectious disease.