Miyata et al. divided the variants found in RYR2 of CPVT and LQTS patients into N-terminal (1–2177 a.a.), central (2178–4075 a.a.), and C-terminal (4076–4959 a.a.)regions and found no significant positional differences between these diseases [61]. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.