Treatment of spleen M-MDSCs with RPMI-C + TES induced the expression of Arg1 (to 10-fold greater than tumor M-MDSCs) and Ccr1 mRNA but had no effect on the expression of Mpo, Nos2, Slc7a11, Spp1, or Vdr mRNA and reduced the expression of Stfa2l1 mRNA levels. This evidence concerns the gene SPP1 and neoplasm.