Furthermore, Tet2–/– mice with myeloid disease also have more pronounced splenomegaly compared with heterozygous (Tet2+/–) littermates (33), and splenomegaly (and extramedullary disease) is a general feature of myeloid disease developing in Tet2-knockout mouse models (10, 34). The gene discussed is TET2; the disease is Splenomegaly.