Furthermore, after 3 hours of myocardial ischemia, Trx1-C73S–KI mice exhibited larger myocardial infarcts, as evaluated with tetrazolium chloride (TTC) staining (Figure 2E), decreases in ejection fraction, an index of cardiac contractile function evaluated by echocardiography (Figure 2F and Supplemental Table 2), and increases in plasma troponin T levels, an index of cardiomyocyte injury, compared with WT mice (Figure 2G). The gene discussed is TXN; the disease is myocardial ischemia.