GPR84 and metabolic dysfunction-associated steatohepatitis: Furthermore, HFD-fed Gpr84–/– mice exhibited increased hepatic inflammation and fibrosis and progression to NASH compared with WT mice (Figure 2, C–E), whereas CDAHFD and CCl4 did not change the basal levels of inflammatory and fibrosis markers nor the NAS between WT and Gpr84–/– mice (Figures 5 and 6).