IDH3A and central nervous system cancer: CD70 was found to be overexpressed on isocitrate dehydrogenase (IDH) primary and low-grade gliomas as well as GBMs and associated with poor survival in the investigated subgroups [27]; further, CD70-specific CAR T cells showed an antitumor response against CD70+ gliomas in xenograft and syngeneic glioma models [27].