In CHME‐3 cells, WT TREM2 expression inhibited the phagocytosis of some targets, and this appeared to be due to the induced expression of cystatin F. Cystatin F, which is expressed from the CST7 gene, is part of the Disease Associated Microglia (DAM) gene profile known to be induced by TREM2 (Keren‐Shaul et al., 2017) and overexpressed in AD brains (Keren‐Shaul et al., 2017; Ofengeim et al., 2017). This evidence concerns the gene TREM2 and Alzheimer disease.