Together with the anti‐PD1, the NPs remodeled the TME in both tumor and lymph nodes by reprogramming M2 to M1 macrophages, improving drug concentration, increasing CD4+ and CD8+ T cells, B cells, and dendritic cells, decreasing regulatory T cells, and preventing T cell exhaustion.[101] Peng et al. The gene discussed is CD8A; the disease is neoplasm.