To explore whether the effect of CHRFAM7A on UUO‐induced renal fibrosis was related to the regulation of inflammatory signalling pathways, we measured the mRNA expression of inflammatory factors such as IL‐1β, IL‐6, TNF‐α and CCL2 in kidneys, as well as IL‐6 protein concentration in the serum and kidney. The gene discussed is CCL2; the disease is renal fibrosis.