Our findings suggested that the overexpression of the human‐specific CHRFAM7A gene can inhibit TGF‐β1‐induced EMT in HK‐2 cells and TGF‐β1/Smad2/3 signal axis, thus, reduce renal fibrosis that develops in response to obstructive nephropathy. The gene discussed is SMAD2; the disease is renal fibrosis.