ACOD1 and infection: Infection of Acod1−/− and littermate Acod1+/− control mice by intraperitoneal injection revealed significantly higher bacterial loads in spleen, liver and lungs of Acod1−/− mice on day 7 (Fig 3D), which was confirmed by immunohistochemistry of liver sections (Fig 3E), demonstrating that ACOD1 is indeed required for the control of C. burnetii in all organs tested.