The strong expression of IFNγ‐induced antimicrobial programs, as indicated by the robust upregulation of gene expression in vivo of IFNγ itself on day 7, of IFNγ protein in liver tissue on day 11, and of Nos2 and Gbp1 mRNA on day 11 after infection (by both intratracheal and intraperitoneal route), likely compensates for the lack of ITA in Acod1−/− mice at this later phase of infection. This evidence concerns the gene IFNG and infection.