Gal-3, a critical regulator of innate immunity in the brain, is deemed crucial for resident microglial activation and has been shown to play a role in AD pathology (Boza-Serrano et al., 2019; Tan et al., 2021), while deletion of Gal-3 in 5xFAD transgenic mice attenuated microglia-associated immune responses (Boza-Serrano et al., 2019). Here, LGALS3 is linked to Alzheimer disease.