XFZYD effectively treats COPD by intervening in the PI3K/AKT pathway, ameliorating oxidative stress and inflammatory responses, relieving the airway remodeling and ventilation disorders, correcting hypercapnia and hypoxemia, and alleviating hypercoagulability of patients, suggesting the consistency between the results of meta-analysis and network pharmacology predictions and revealing an important mechanism for the treatment of COPD with XFZYD. Here, AKT1 is linked to chronic obstructive pulmonary disease.