In cultures exposed to OM-85, upregulation of IFN signaling, was accompanied by, (i) network rewiring resulting in increased coordination of TLR4 expression with IFN pathway–associated genes (especially master regulator IRF7); ii) segregation of TNF and IFN-γ (which potentially synergize to exaggerate inflammatory sequelae) into separate expression modules; iii) reduced size/complexity of the main proinflammatory network module, containing, IL-1, IL-6, and CCL3. This evidence concerns the gene TNF and ocular melanoma.