Strong activation of genes specifically linked to type 1 IFN signaling and innate immunity was observed but in OM-85-treated animals, the reduced viral stress starting at day 4, was associated with a significant downregulation of IFN-α, IFN-β, IFN-γ, and induced protein with tetratricopeptide repeats 1 (IFIT1) mRNA levels in lung tissue (62). This evidence concerns the gene IFNA1 and ocular melanoma.