LAMC1 mediates cortical histogenesis and its abnormal expression results in disrupted basement membrane structure and cortical dysplasia.93 Laminin protein disruption associated with cortical heterotopias in man94. LAMC1 shows genetic association with cortical folding and thickness,95, 96 the latter robustly differentiating ADHD, autism and schizophrenia cases from controls97, 98. This evidence concerns the gene LAMB2 and autism.