In order to verify the clinical diagnostic efficacy of CTC combined with GNB4 and Riplet gene methylation detection in plasma for HCC patients, ROC analysis was further performed for CTC count detection combined with GNB4 and Riplet gene methylation detection in the above two groups of patients, and the results were shown in Figure 5: The specificity of CTC combined with GNB4 was 90.9%, and that of CTC combined with Riplet was 100%. Here, GNB4 is linked to hepatocellular carcinoma.