CTNNB1, TP53, RB1, ADCY8, MYC, PTK2, PRKCA, TP53, TCF7L2, PAK1, ITPR2, CYP3A4, UGT1A6, CTNNB1, GCK, and FGFR2/3 were among the genes whose alterations could possibly alter a large number of critical biological functions including those which directly infer the cancer mainly the HCC pathways. The gene discussed is RB1; the disease is cancer.