Moreover, we also found no significant changes in the expression levels of ALKBH5. Although ALKBH5 has been reported to selectively demethylate BCL2 transcripts after cerebral ischemia, which prevents degradation of B-cell lymphoma-2 (BCL2) mRNA, enhances expression of anti-apoptotic BCL2 protein, and inhibits neuronal apoptosis, the role of ALKBH5 is still less understood (Xu et al., 2020b). The gene discussed is BCL2; the disease is brain ischemia.