METTL3 and brain ischemia: Therefore, we further investigated the expression levels of five common m6A methyltransferases and demethylases and found that FTO expression was downregulated after CIRI, while no significant changes were observed in the expression of methyltransferases, including METTL3, WTAP, and METTL14. The high expression of METTL3, WTAP, and METTL14 may lead to an increase in the m6A methylation level (Zhang et al., 2022), but at present, there are few reports related to cerebral ischemia, which need to be further studied.