Up to the present day, limited studies have shown that EXOC3L1 were involved in the regulation of insulin secretion (Saito et al., 2008), protein secretion after traumatic brain injury (Tang et al., 2020), spontaneous induction of apoptosis (Matsumoto et al., 2021), and high-density lipoprotein concentration (Lanktree et al., 2015), but the exact function of EXOC3L1 remains unclear. The gene discussed is EXOC3L1; the disease is brain injury.