The variations in MLPH gene could cause transport defect melanosomes in melanocytes, resulting in the dilution of coat or plumage colors in cats (Ishida et al., 2006), dogs (Bauer et al., 2018; Drögemüller et al., 2007; Van Buren et al., 2020), cattle (Li et al., 2016), sheep (Posbergh et al., 2020), rabbits (Demars et al., 2018; Jia et al., 2021), and minks (Cirera et al., 2013), as well as Griscelli syndrome type-3 in humans (Al-Mousa et al., 2016; Çağdaş et al., 2012; Gironi et al., 2019; Jo et al., 2020; Ménasché et al., 2005). This evidence concerns the gene MLPH and Griscelli disease.