To clarify the binding activity among target proteins and corresponding components, the top six targets (i.e., PTGS2, PIK3CA, PIK3CB, PIK3CD, F2, and AR) in the C-T-P network diagram of the SAHP for the treatment of migraine and the top six active ingredients (i.e., wogonin, anomalin, imperatorin, prangenin, 2-linoleoylglycerol, and methylenetanshinquinone) underwent molecular docking separately Based on the same method, subsequently, 36 groups of receptor-ligand docking consequences were obtained. The gene discussed is PIK3CA; the disease is migraine disorder.