IDH1 and central nervous system cancer: In glioma, results of phase I trial NCT02454634 recently published in Nature (202) showed that topical Imiquimod combined with IDH1 peptide vaccine induced 93.3% immune responses in IDH1R132H-mutated patients while adverse effects are within grade I. The immune responses induced by the treatment were represented by enhanced IL-17 production and increased IDH1-specific T cells (202).