TNF and Familial prostate cancer: Through a gene enrichment analysis, we found that extracellular matrix disassembly, collagen catabolic process, granulocyte chemotaxis, granulocyte migration, and myeloid leukocyte migration were the top five enriched BPs, while the IL-17 signaling pathway, prostate cancer, TNF signaling pathway, transcriptional misregulation in cancer, and rheumatoid arthritis were the top five enriched KEGG pathways (Figure 4F and details in Supplementary Table 5).