Through a gene enrichment analysis, we observed that extracellular matrix disassembly, collagen catabolic process, collagen metabolic process, extracellular matrix organization, and extracellular structure organization were the top five enriched BPs, while the IL-17 signaling pathway, TNF signaling pathway, rheumatoid arthritis, prostate cancer, and NF-kappa B signaling pathway were the top five enriched KEGG pathways (Figure 4C and details in Supplementary Table 5). The gene discussed is TNF; the disease is rheumatoid arthritis.