TNF and rheumatoid arthritis: In the UC samples, negative regulation of proteolysis, extracellular matrix organization, collagen catabolic process, extracellular matrix disassembly, and extracellular structure organization were the top five enriched BPs, while the IL-17 signaling pathway, rheumatoid arthritis, cytokine−cytokine receptor interaction, NF-kappa B signaling pathway and TNF signaling pathway were the top five enriched KEGG pathways.