The enriched top 10 KEGG pathways included the Prkce-mediated Type II diabetes mellitus、Fc gamma R-mediated phagocytosis AGE-RAGE signaling pathway in diabetic complications Aldosterone synthesis and secretion、Insulin resistance、Sphingolipid signaling pathway and Inflammatory mediator regulation of TRP channels, Bcl2l13-mediated Legionellosis and Mitophagy, and Nf1-mediated EGFR tyrosinekinase inhibitor resistance (Figures 6G, H). Here, PRKCE is linked to legionellosis.