Of the 81 IICDLs, 20 were significantly associated with prognosis of patients with HCC, namely, AL606489.1, AC004160.1, AC099508.2, TMEM220-AS1, AC079061.1, AC115619.1, LINC02754, LINC02037, AC008549.1, AP001065.3, LINC01018, LINC00261, LINC02362, AC009093.5, AC079466.1, LINC01554, AC010280.2, AP001781.1, LINC02499, and AL161645.2. The gene discussed is TMEM220; the disease is hepatocellular carcinoma.