YAP1 and cancer: High expression of YAP1 may inhibit the infiltration of CD8+ T cells in 21 of the 33 cancer types (BLCA, BRCA, COAD, HNSC, KIRC, KIRP, LGG, LIHC, LUAD, LUSC, OV, MESO, PCPG, PRAD, SARC, SKCM, TGCT, THCA, THYM, UCEC, and UCS), indicating its immunosuppressive role in TME (Figure 4B).