CLDN2 and neoplasm: Intriguingly, the expression of the four tumor suppressor genes (FCGRT, TEK, semaphorin 3G (SEMA3G), and fatty acid binding protein 3 (FABP3)) was significantly positively correlated with that of claudin genes, whereas the risk genes were shown to be negatively correlated with claudin genes, particularly claudins 2, 3, 4, 5, and 10 (Figure 7F).