An immunohistochemistry (IHC) test of the ccRCC samples from the CheckMate studies showed a significantly higher level of CD8 + tumor cell (TC) ratio and CD8 + tumor margin (TM) density, which were found in the high CTR group, supporting the positive correlation between CTR score and CD8 T cells found using the algorithms (Figure 9F). This evidence concerns the gene CD8A and neoplasm.