We first compared the expression of CRGs between tumor samples and normal samples from TCGA-STAD database, and found that 16 CRGs were up-regulated in tumor tissues, including NLRP3, ATP7A, ATP7B, SLC31A1, FDX1, LIAS, LIPT1, LIPT2, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, CDKN2A, and GCSH (Figure 1A). This evidence concerns the gene PDHA1 and neoplasm.