GLS and neoplasm: We first compared the expression of CRGs between tumor samples and normal samples from TCGA-STAD database, and found that 16 CRGs were up-regulated in tumor tissues, including NLRP3, ATP7A, ATP7B, SLC31A1, FDX1, LIAS, LIPT1, LIPT2, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, CDKN2A, and GCSH (Figure 1A).