The three most frequently mutated pathways in the MSS-CRC cases from TCGA were SWI_SNF, Histone_methylase, and CHD (Figure 1A), and the epigenetic-related genes ARID1A, KMT2C, and RSF1 had the highest mutation rates in the TCGA cohort (Figure 1B). This evidence concerns the gene CHDH and colorectal carcinoma.