PTPN14 and cervical cancer: For example, in 2020, a study found that binding of the E7 oncoprotein of HPV16 and HPV18 to the host tumor suppressor PTPN14 would inhibit the expression of differentiation genes and demonstrated experimentally that mutating the PTPN14 gene in cervical cancer cells by CRISPR-Cas9 would significantly reduce the oncogenic activity of HPV viruses (50).