CXCR3 ligands play an essential role in IL-7/IL-7Rα-Fc-mediated anti-tumor activity. Neutralizing CXCL9, CXCL10, or IFNγ reduces CXCR3-expressing activated T cell infiltration into tumors and abrogates IL-7/IL-7rα-Fc-mediated tumor growth inhibition. Here, IL7R is linked to neoplasm.