The chemokine receptor axis is prominent in esophageal adenocarcinoma, with a fold change of up to 9.5. Its immune regulation is mainly driven by the chemokine CXCR3/CCR5 axis and cytotoxic effector mechanisms essential for T cell activation and differentiation to promote cancer cell proliferation and metastasis. Here, CCR5 is linked to esophageal adenocarcinoma.