In the TME, CXCL9, CXCL10, and CXCL11 are mainly secreted by monocytes, endothelial cells, fibroblasts, and tumor cells and mediate the migration, differentiation, and activation of immune cells by recruiting various immune cells (CTL, NK cells, macrophages, etc.)in an autocrine and paracrine manner (31, 142). The gene discussed is CXCL11; the disease is neoplasm.