One study induced CXCL9 and CXCL10 by adjuvant injection into the lymph nodes of melanoma patients to promote homing of tumor cells to inflamed lymph nodes; CXCR3 was detected by immunohistochemistry in approximately one-third of tumor specimens, and its expression was positively correlated with tumor size and the presence of distant metastases (95). This evidence concerns the gene CXCL9 and neoplasm.