Interferon (IFN)-γ-inducible protein (IP)-10 (IP-10) is a potent angiogenesis inhibitor that recruits CXCR3+ T cells, including CD8+ T cells. In the presence of IP10-scFv and EGFRvIII peptide pulses, DC-induced CTL synergistically inhibits glioma growth while suppressing tumor angiogenesis and enhancing cytotoxicity, thereby increasing the number of brain-infiltrating lymphocytes (BILs) and prolonging CTL residence in the tumor. This evidence concerns the gene CXCL10 and central nervous system cancer.