In the metastatic prostate, significantly higher expression of ELR+CXC chemokines/receptors and significantly lower expression of ELR-CXC chemokines/receptors were observed in bone metastases relative to lymph node metastases, and co-expression of CXCL10/CXCR3 was associated with postoperative recurrence. This evidence concerns the gene CXCR3 and metastatic malignant neoplasm in the lymph nodes.