The chemokine receptor axis is prominent in esophageal adenocarcinoma, with a fold change of up to 9.5. Its immune regulation is mainly driven by the chemokine CXCR3/CCR5 axis and cytotoxic effector mechanisms essential for T cell activation and differentiation to promote cancer cell proliferation and metastasis. This evidence concerns the gene CXCR3 and esophageal adenocarcinoma.