Similar to YTHDF1 and YTHDF2, PD-L1 expression is a poor prognostic factor in NSCLC (44, 45); however, the higher is the expression of PD-L1, the higher is the response rate to PD-1/PD-L1 inhibitor (4). The gene discussed is YTHDF1; the disease is non-small cell lung carcinoma.