Moreover, the iCCAphl and iCCApps groups showed significant differences in the proportion of cases with preoperative jaundice (5 [13.5%] vs. 0 [0.0%]), hepatic vascular invasion (10 [27.0%] vs. 4 [7.7%]), lymph node metastasis (16 [43.2%] vs. 5 [9.6%]), preoperative carcinoembryonic antigen >10 ng/mL (19 [51.4%] vs. 7 [13.5%]), preoperative carbohydrate antigen 19-9 >39 U/mL (29 [78.4%] vs. 26 [50.0%]), hepatitis B infection (8 [8.1%] vs. 14 [26.9%]), and resection of >2 liver segments (32 [86.5%] vs. 17 [32.7%]). Here, CEACAM5 is linked to metastatic malignant neoplasm in the lymph nodes.