BRAF and neoplasm: In a national pediatric cohort study, lower tumor grade, GTR, non-brainstem location and age >1 year at diagnosis were all associated with longer OS.60 Recent clinical and molecular characterization has underscored the importance of single-nucleotide variant (SNV) and rearrangements in the pathobiology of pediatric LGG with SNV-driven tumors exhibiting inferior OS.5 Several molecular factors have important prognostic implications in pediatric LGG including mutations in BRAF V600E, KIAA1549-BRAF and NF-1 along with other less commonly encountered oncogenes.