To systematically test the association between HMGA1 expression and specifical receptors, 2509 breast cancers in “cBioportal” and 4384 breast cancers in “bc-GenExMiner” were analyzed, respectively, and got the consistent conclusions; high HMGA1 expression was found in ER-negative group, PR-negative group, and HER2-positive group and was significantly related with high-grade pathological group and lymph node metastasis. This evidence concerns the gene ERBB2 and metastatic malignant neoplasm in the lymph nodes.